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PETER SALZBURG, M.D.; HERMAN KABAT, Ph.D.

Arch Surg. 1941;42(5):917-928.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Warburg, Wind and Negelein¹ suggested that tumor cells should be particularly sensitive to lack of nutrition because of their high metabolic rate. This conception seems to be borne out by the fact that Jensen's sarcoma undergoes extensive necrosis in rats which are exposed to 5 per cent oxygen for forty hours.¹ Okamoto² and Warburg. Wind and Negelein¹ have shown that tumor cells remain viable after prolonged exposure to environments lacking either dextrose or oxygen. In a medium lacking both dextrose and oxygen, however, tumor cells die very rapidly; so it was found impossible to transplant the Jensen sarcoma after only four hours in such a medium. Furthermore, when a tumor-bearing animal was killed and kept at 37 C. for four hours after death, slices of tumor tissue placed in a medium containing dextrose and oxygen no longer metabolized, indicating irreversible destruction of the tumor cells.¹ . . . [Full Text PDF of this Article]

Author Affiliations
MINNEAPOLIS

From the Department of Physiology, the University of Minnesota.

Footnotes
Aided by a grant from the Committee on Scientific Research of the American Medical Association.

Assistance in the preparation of these materials was furnished by the Personnel of Work Projects Administration, Official Project 65-1-71-140, Subproject 309.

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