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CLINICAL AND EXPERIMENTAL OBSERVATIONS

J. M. McCAUGHAN, M.D., Ph.D.; H. K. PURCELL, M.D.

Arch Surg. 1941;43(2):269-283.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Although Wirsung¹ as early as 1645 had discovered the pancreatic duct and described the fluid which flows through it and DeGraaf² in 1664 had collected some of this fluid, using a wild duck's quill for a cannula, present knowledge of the physiology of the external function of the pancreas came largely as a result of the work of four investigators in the late part of the nineteenth and the early part of the twentieth century, namely, Bernard,³ Pavlov⁴ and Bayliss and Starling.⁵ Bernard in 1856 showed that pancreatic juice is essential to digestion. Pavlov in 1902 demonstrated the existence of pancreatic enzymes, and in the same year Bayliss and Starling investigated the factors concerned in the secretory stimulus of the pancreas and assigned the important role to a humoral factor, which they named secretin.

McClure⁶ has enumerated as follows the important physiologic facts, which . . . [Full Text PDF of this Article]

Author Affiliations
ST. LOUIS

From the Department of Surgery, St. Louis University School of Medicine.

Footnotes
Read at the Fiftieth Annual Meeting of the Western Surgical Association, Topeka, Kan., Dec. 5, 1940.

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