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XV. EXPERIMENTAL OBSERVATIONS ON HYPERTENSION ASSOCIATED WITH UNILATERAL RENAL DISEASE; EFFECT OF OCCLUSION OF THE URETER ON EXPERIMENTAL HYPERTENSION DUE TO UNILATERAL RENAL ISCHEMIA

HARRY GOLDBLATT, M.D.; JOSEPH R. KAHN, M.D.; HARVEY A. LEWIS, M.D.

Arch Surg. 1941;43(3):327-340.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

In the earliest studies on experimental hypertension due to renal ischemia¹ it was shown that constriction of the main artery of only one kidney in a dog or a monkey is sufficient to cause elevation of the blood pressure. It was also shown in these and in later studies² that this elevation does not usually persist indefinitely unless the other kidney is removed or unless the main artery of the other kidney is also constricted. In most dogs with unilateral renal ischemia the blood pressure returns to the preoperative level in six weeks or less, but in some the hypertension may persist at a high level for many months. The return of the blood pressure to normal obviously may be due (a) to the development of considerable accessory circulation to the ischemic kidney or (b) to the compensating, neutralizing or inhibiting effect of the contralateral normal kidney. The . . . [Full Text PDF of this Article]

Author Affiliations
CLEVELAND; LOS ANGELES

From the Institute of Pathology, the Western Reserve University.

Footnotes
A preliminary report was presented before the Central Society for Clinical Research, Chicago, Nov. 1, 1940.

This study was supported by the Beaumont Trust (L. D. Beaumont) and the Josiah Macy Jr. Foundation. It was aided by grants from Mr. Nathan Richman, Mr. Richard Kohn, Mr. Nathan Dauby and Mr. Alex Wintner and his associates, of Cleveland.

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