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REACTION OF THE APPENDIX TO DRUGS

CLARENCE DENNIS, M.D.

Arch Surg. 1941;43(6):1021-1060.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

PART 1. INTRODUCTION

I. PURPOSE OF THIS STUDY

Although a host of theories as to the etiology of acute appendicitis has been offered, many with strong supporting evidence, the disease has not been proved capable of experimental production either in man or in related species except by the obstructive mechanism.¹

By longitudinal section of 91 surgically removed appendixes fixed in solution of formaldehyde, Wangensteen and Bowers² found all the gangrenous specimens to show obstruction of the lumen, but in only 72 per cent of 43 cases of acute suppurative appendicitis was obstruction demonstrable by this method, leaving 28 per cent of the group, or 12 cases, in which no obstruction could be demonstrated.

Through the studies reported in this paper it has been shown that a functional factor exists which may reasonably explain the absence of organic obstruction in some cases. Experiments will be outlined which have approached . . . [Full Text PDF of this Article]

Author Affiliations
MINNEAPOLIS

From the Department of Surgery, University Hospitals.

Footnotes
Partially supported by a grant for technical assistance from the Work Projects Administration, Official Project 165-1-71-124, Subproject 399.

A condensation of a thesis submitted to the faculty of the Graduate School of the University of Minnesota in partial fulfilment of the requirements for the degree of Doctor of Philosophy in Surgery.

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