This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

J. LEWI DONHAUSER, M.D.; WILLIAM H. de ROUVILLE, M.D.

Arch Surg. 1941;43(6):946-1020.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

In 1928, Ewing¹ defined multiple myeloma as... a specific malignant tumor of the bone marrow arising probably from a single cell-type and characterized chiefly by multiple foci of origin, a uniform and specific structure composed of plasma cells or their derivatives, rare metastases, albumosuria and fatal termination.

Vance,² considering the disease more from the clinical than from the pathologic standpoint, described multiple myeloma as characterized by... multiple primary tumors of the bone marrow, occurring, for the most part, in elderly individuals, and manifested during life by deep-seated pain in the bones, characteristic deformities of the skeleton, spontaneous fractures in many bones of the body, severe secondary anemia, and emaciation.

Geschickter and Copeland³ emphasized that the... disease not only produces extensive involvement of the skeleton, but the systemic manifestations are particularly widespread and that changes in the central nervous system, the thorax, the lungs, the kidneys and in . . . [Full Text PDF of this Article]

Author Affiliations
ALBANY, N. Y.

From the Department of Surgery of Albany Hospital and Albany Medical College.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?