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CORNELIUS VERMEULEN, M.D.; LESTER R. DRAGSTEDT, M.D.; DWIGHT E. CLARK, M.D.; ORMAND C. JULIAN, M.D.; J. GARROTT ALLEN, M.D.

Arch Surg. 1942;44(2):260-267.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

If rabbits are fed cholesterol in excessive amounts, a marked and sustained elevation of the blood cholesterol level occurs, and after a few months progressive intimal changes appear in the aorta.¹ Cholesterol and other lipids² are deposited in the inner layers of the aorta, and gradually lesions develop which assume most of the characteristics of human arteriosclerosis.³ These findings suggest that this disease may be the result of some metabolic defect and not a necessary accompaniment of the aging process. The abnormally high incidence of presenile arteriosclerosis in patients with diabetes mellitus supports this view. Here also there is evidence that some disturbance in fat metabolism resulting in sustained hypercholesteremia is involved. Rabinowitch,⁴ Joslin⁵ and others have demonstrated that high fat diets given to patients with diabetes favor, and that, conversely, low fat—high carbohydrate diets retard, the appearance of hypercholesteremia and arteriosclerosis. The discovery in . . . [Full Text PDF of this Article]

Author Affiliations
CHICAGO

From the Department of Surgery, the University of Chicago.

Footnotes
This work has been aided by grants from the Josiah Macy Jr. Foundation, the Committee on Research in Endocrinology of the National Research Council, Eli Lilly & Company and the Douglas Smith Foundation for Medical Research of the University of Chicago.

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