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WITH SPECIAL REFERENCE TO GASTRODUODENAL ULCER

J. P. QUIGLEY, Ph.D.

Arch Surg. 1942;44(3):414-437.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Numerous experimental methods are known which lead to ulceration of the stomach. Of these methods, the greatest significance is attached to those employed by Exalto, Mann, Ivy, Dragstedt and others, who produced chronic peptic ulcer by experimental alterations in gastro-intestinal function. The ulcer thus produced resembles grossly and histologically the clinical lesion, and both respond in a similar manner to therapy. From such studies more is already known regarding the basic factors causing or curing the experimental lesion than those influencing the spontaneous ulcer, and the information available with respect to both lesions exceeds that regarding ulcer in other and frequently more accessible portions of the body.

The studies on experimentally produced ulcers have greatly revived interest in the fundamental ulcer problems—why ulcers form, become chronic, undergo hemorrhage or perforate and how they can be prevented or healed. So far, the investigations have been most fruitful in establishing the fundamental . . . [Full Text PDF of this Article]

Author Affiliations
CLEVELAND

From the Department of Physiology, Western Reserve University School of Medicine.

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