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AN EXPERIMENTAL STUDY

BARNARD KLEIGER, M.D.; JOHN E. BLAIR, Ph.D.; FRANCES A. HALLMAN, Sc.M.

Arch Surg. 1942;45(4):571-577.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

The full role of exotoxin in the pathogenesis of systemic staphylococcic infections has not yet been demonstrated.¹ The symptoms of systemic infections in human beings due to toxigenic staphylococci differ from the symptoms of those due to nontoxigenic staphylococci,² and this difference is sufficiently pronounced to make it possible to determine from clinical characteristics alone whether the symptoms are primarily due to the effect of staphylococcic exotoxin.^2d Previous reports have described the clinical response of the rabbit³ and more specifically of the rabbit heart⁴ to the intravenous injection of exotoxin. With these clinical and experimental reports as a point of departure, the purpose of the present work is to extend these observations by comparing the clinical and electrocardiographic responses in rabbits receiving intravenous injections of staphylococcus exotoxin and toxinfree suspensions of living toxigenic or nontoxigenic staphylococci.

METHODS

Rabbits averaging 2,300 Gm. in weight were used. . . . [Full Text PDF of this Article]

Author Affiliations
NEW YORK

From the Laboratory Division, Hospital for Joint Diseases.

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