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A STUDY WITH SPECIAL REFERENCE TO THEIR LOCAL USE IN WOUNDS

CHARLES L. FOX, Jr., M.D.

Arch Surg. 1942;45(5):754-763.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

At present sulfanilamide is the accepted sulfonamide compound for local use in war wounds, compound fractures and the peritoneum.¹ Experiments in vitro, however, have clearly shown that sulfadiazine (2-[paraaminobenzenesulfonamido]-pyrimidine) and sulfathiazole (2-[paraaminobenzenesulfonamido]-thiazole) are more potent antibacterial agents than sulfanilamide and are also far more resistant to drug inhibitors, such as paraaminobenzoic acid.² Actually, against Escherichia coli (frequently a participant in peritonitis following intra-abdominal wounds) 1 mg. of sulfathiazole or sulfadiazine can accomplish as much as 430 mg. of sulfanilamide. To obtain bacteriostasis, furthermore, in the presence of 1 mg. per hundred cubic centimeters of paraaminobenzoic acid (or similar inhibitor of drug action) 15 mg. per hundred cubic centimeters of sulfadiazine or sulfathiazole is required, whereas 6,280 mg. per hundred cubic centimeters of sulfanilamide is necessary! Clinical experience has also demonstrated the superiority of these newer drugs over sulfanilamide and sulfapyridine (2-[paraaminobenzenesulfonamido]-pyridine).³ Nevertheless, these drugs have not supplanted . . . [Full Text PDF of this Article]

Author Affiliations
NEW YORK

From the Department of Bacteriology, Columbia University College of Physicians and Surgeons.

Footnotes
The drugs used in this study were provided by the Lederle Laboratories, Inc.

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