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JOSEPH J. LALICH, M.D.; ALFRED L. COPLEY, M.D.

Arch Surg. 1943;46(2):224-237.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

During previous studies we found that movement of the tail had a slight effect or none in prolonging the duration of bleeding from a wound in the tail in normal mice. In heparinized mice, however, such movements initiated bleeding which persisted several minutes.¹ We also observed that some of the mice treated with heparin or dicoumarin (3,3'-methylene-bis-[4-hydroxycoumarin])² which had normal bleeding times continued to bleed spontaneously from the same wound after completion of the test. In an attempt to elucidate the lack of correlation between the bleeding time and this tendency to spontaneous bleeding from the same prick wound, further experiments were done. Macfarlane³ has drawn attention to the fact that there is no satisfactory method to test the toughness of blood clots. We proposed to estimate clot resistance,⁴ that is, the firmness of a clot and its adhesiveness, in a wound in the tail of . . . [Full Text PDF of this Article]

Author Affiliations
KANSAS CITY, KAN.; NEW YORK

From the Hixon Laboratory for Medical Research, University of Kansas School of Medicine, Kansas City.

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