This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

LIEUTENANT LEO L. LEVERIDGE

Arch Surg. 1944;48(5):366-371.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Hemorrhoidectomy is an elective operative procedure, traditionally performed in a contaminated field. The presence of large numbers of potentially pathogenic bacteria in this operative site, and flowing over the healing wounds postoperatively, has always had to be accepted as unavoidable. With recent developments of chemotherapy, means appear now within reach to alter these conditions.

Two drugs, sulfanilylguanidine and succinylsulfathiazole,¹ have been reported to decrease the bacterial flora in the gastrointestinal tract, apparently without excessive systemic absorption. The newer drug, succinylsulfathiazole,² appears to be less toxic and yet to be as effective as sulfanilylguanidine, with the additional advantage of being effectual in the presence of ulcerating lesions of the bowel.³

CHEMISTRY OF SUCCINYLSULFATHIAZOLE

Structurally, succinylsulfathiazole is a succinic acid derivative of sulfathiazole. It is relatively strongly acid in reaction. Its solubility in water is low, 0.070 Gm. dissolving in 100 cc. of water at 37 C. However, the . . . [Full Text PDF of this Article]

Author Affiliations
MEDICAL CORPS, ARMY OF THE UNITED STATES

Footnotes
This study was made possible by the cooperation of the following officers of the Medical Corps of the Army of the United States on the staff of the Station Hospital, Camp Blanding, Fla.: Major J. V. Freeman, Chief of the Surgical Service; Major J. E. Ryan, Chief of Septic Surgery, and Major J. T. Cuttino, Chief of the Laboratory Service. The problem was suggested by Major J. W. Annis, Chief of the Gastrointestinal Section of the Medical Service, and the work could not have been done without the assistance of Major A. Fodor, Sanitary Corps, Army of the United States. Assistant to the Chief of the Laboratory Service.

Dr. E. J. Poth, Galveston, Tex., and Dr. E. L. Burbidge, Sharp and Dohme, Philadelphia, made many helpful suggestions.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?