This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on Web of Science (45)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

DEVELOPMENT OF A MORE SUITABLE PREPARATION FOR MEASURING ACCELERATED CLOTTING TENDENCY AND FOR USE FOLLOWING ADMINISTRATION OF DICOUMARIN (3,3'-METHYLENE-BIS-[4-HYDROXYCOUMARIN])

CHARLES E. BRAMBEL, Ph.D.

Arch Surg. 1945;50(3):137-147.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

It is a well established fact that in certain clinical conditions, especially those following surgical procedures and trauma, the equilibrium of the coagulation elements of the blood is shifted to a state favorable to clotting.¹ A laboratory procedure is needed for detecting this tendency to intravascular clotting before the appearance of thrombotic phenomena. If such a procedure were available to the clinician, in vivo anticoagulants, such as heparin or dicoumarin (3,3'-methylene-bis [4-hydroxycoumarin] ), could be administered to patients having indications of such a tendency. Serious consequences and long periods of hospitalization could be averted in many instances. The introduction of dicoumarin,² however, has posed another problem, that of maintaining a precise control of the mechanism for blood coagulation in order to avoid hemorrhagic consequences following the use of this drug. Difficulty in maintaining a given clotting level, as well as undesirable results, including death, has been reported.³

A . . . [Full Text PDF of this Article]

Author Affiliations
BALTIMORE

From the Department of Clinical Biochemistry, Mercy Hospital.

Footnotes
Mrs. Raymond C. Teubner, B.S., M.T., carried out the technical work.

This investigation has been made possible through a grant in aid by the Abbott Laboratories, North Chicago, Ill.

Prof. Alsoph H. Corwin, of the Department of Chemistry, the Johns Hopkins University, and Dr. Karl J. Brunings, of the Department of Chemistry, New York University, made suggestions as to the chemical problems involved.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?