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I. The Changes in the Histamine Content and the Coagulability of the Blood in Guinea Pigs and in Dogs

M. ROCHA e SILVA; R. GRAÑA

Arch Surg. 1946;52(5):523-537.

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IN a preceding paper, we have studied¹ the mechanism of shock produced by hydatid fluid (Taenia echinococcus) when injected into dogs. We have reached the conclusion that the material responsible for the shock is not precipitated by 5 per cent trichloroacetic acid, does not dialyze through cellophane paper and resists boiling temperature for a long time. From those preliminary studies we have been able to obtain a fairly purified material which produces profound shock in dogs. This shock is of the indirect type, since a second injection of the same material does not produce any appreciable effect (desensitization). Furthermore, in certain cases there occurred an evanescent incoagulability of the blood and in a few animals complete incoagulability was observed, suggesting a liberation of heparin from tissues into the blood stream. Histamine was found to be increased in the circulating blood in a few animals but in most of the . . . [Full Text PDF of this Article]

Author Affiliations
SAO PAULO, BRAZIL

From the Department of Biochemistry and Pharmacodynamics, Instituto Biologico.

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