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II. The Mechanism of the Shock Induced in Dogs

M. ROCHA e SILVA; A. GRANA

Arch Surg. 1946;52(6):713-728.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

IT is a well known fact that leukopenia and thrombopenia regularly accompany anaphylactic shock in every species of animals.¹ In 1924 Webb² made an extensive study of the leukopenia which occurs in sensitized dogs as a consequence of the injection of the antigen. Recently, Kopeloff and associates³ and Kinsell and co-workers⁴ have shown that a decrease in platelets is definitely proportionate to the gravity of the anaphylactic shock in monkeys and rabbits. They have also postulated that a rupture of those hematologic elements might help to explain the liberation of histamine, since rabbit platelets are especially rich in histamine.⁵ In the case of dogs, however, it is not so easy to explain the increase of histamine in the blood as a consequence of an explosion of platelets, since those elements are very poor carriers of histamine in this species of animal. Moreover, it has been . . . [Full Text PDF of this Article]

Author Affiliations
SAO PAULO, BRAZIL

From the Department of Biochemistry and Pharmacodynamics, Instituto Biologico.

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