This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citing articles on Web of Science (5)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Their Use in the Prophylaxis and Treatment of Peritonitis

JOHN P. YOUNG, Jr., M.D.; WARREN H. COLE, M.D.

Arch Surg. 1946;53(2):182-189.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

SHORTLY after the introduction of the sulfonamide drugs as antibiotics, they were used intraperitoneally as a prophylaxis against peritonitis. Innumerable reports indicated that they were effective, but most surgeons abandoned their intraperitoneal use when penicillin was made available, because it appeared to be more effective than the sulfonamide compounds. Of these two drugs penicillin appears definitely to be more helpful against colon bacilli, but neither can be classified as being extremely effective against these organisms. Although streptococci and other pyogenic bacteria are occasionally isolated as causative organisms in peritonitis Escherichia coli is much commoner and even when a mixed infection occurs it is usually the predominant organism. Therefore, in the treatment or prophylaxis of peritonitis there would appear to be a need for an antibiotic agent which would be more effective against Esch. coli.

The introduction of the oral use of succinylsulfathiazole in 1941 by Poth and Knotts¹ and, . . . [Full Text PDF of this Article]

Author Affiliations
CHICAGO

From the Department of Surgery, University of Illinois College of Medicine and the Illinois Research and Educational Hospitals.

Footnotes
Mr. Everett Hoppe gave able assistance.

Aided by a grant from Sharp & Dohme, Inc.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?