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PAUL NEMIR, Jr., M.D.; H. R. HAWTHORNE, M.D.; BURNETTA L. LECRONE, M.S.

Arch Surg. 1949;59(2):337-347.

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THE USE of determinations of serum amylase and serum lipase in the diagnosis of diseases involving the pancreas has achieved great prominence during the past ten years.¹ Increases of serum amylase have been reported in cases of acute pancreatitis,² perforation of peptic ulcer into or near the pancreas³ and trauma to the pancreas.⁴ High transient increases have been obtained experimentally in cases of complete obstruction of the pancreatic ducts.⁵ and a continued increase for over a year following permanent closure of the ducts has been reported.⁶ Hyperamylasemia has also been observed in diseases of the salivary glands such as mumps,⁷ although here also some investigators have ascribed the increase to transient pancreatitis.⁸ The mass of evidence at hand,^7b,c however, would indicate that the high amylase level in cases of mumps occurs most frequently without evidence of involvement of the pancreas.

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Author Affiliations
PHILADELPHIA

From the Harrison Department of Surgical Research, School of Medicine, and the Graduate School of Medicine, University of Pennsylvania.

Footnotes
Supported by a grant from the National Drug Company, Philadelphia.

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