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EDWARD J. HILL, M.D.; JOHN M. HAMMER, M.D.; HARRY C. SALTZSTEIN, M.D.; CLIFFORD D. BENSON, M.D.

Arch Surg. 1949;59(3):527-541.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

IN THEIR study of quaternary ammonium compounds, Burns and Dale¹ found that tetraethylammonium chloride (TEAC) had a nicotine-like action but was void of either a curare-like or muscarine-like action. The more recent studies of Acheson and Moe² showed the action of tetraethylammonium chloride to be one of blockade of the cholinergic ganglions of the sympathetic and parasympathetic nervous systems. After administration of tetraethylammonium chloride the effects of preganglionic stimulation are abolished but not the effects of postganglionic stimulation or of drugs with a peripheral action. According to Loewi,³ the mechanism of autonomic blockade by tetraethylammonium chloride still remains to be explained.

The generalized autonomic ganglion blockade produced by this drug results in a transient fall in systemic blood pressure and an increase in both peripheral blood flow and skin temperature. These effects, due to the removal of vasoconstrictor tone by action on the sympathetic ganglions, suggested the . . . [Full Text PDF of this Article]

Author Affiliations
DETROIT

From the Experimental Surgical Laboratory, Harper Hospital.

Footnotes
Read at the Sixth Annual Meeting of the Central Surgical Association, Cleveland, Feb. 18, 1949.

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