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S. H. GRAY, M.D.; J. G. PROBSTEIN, M.D.; LEO A. SACHAR, M.D.

Arch Surg. 1949;59(5):1007-1014.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

IN AN EARLIER communication¹ it was shown that division of the sphincter of Oddi of dogs was followed by the appearance of diastase in the bile obtained from cholecystostomy tubes placed in such dogs. Normally, bile contains no diastase or negligible amounts of it. The effects of a prolonged reflux of duodenal contents into the gallbladder were obscured by the irritative effect of the cholecystostomy tube.

The present experiments were designed to determine (1) whether section of the sphincter of Oddi is followed by reflux of duodenal contents into the gallbladder when the latter is not decompressed by a cannula and (2) what the effects are of prolonged duodenal reflex through an incompetent sphincter of Oddi.

Observations relating to these problems have been described by Colp, Doubilet and Gerber.² These authors divided the sphincteric mechanism of the common duct of 3 dogs by inserting a specially designed sphincterotome . . . [Full Text PDF of this Article]

Author Affiliations
ST. LOUIS

From the Laboratory and Department of Surgery of the Jewish Hospital of St. Louis, and the Department of Surgery, Washington University School of Medicine.

Footnotes
Aided by the David May-Florence G. May Fund.

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