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EFFECT OF VAGOTOMY ON GASTRIC SECRETION IN MAN AND EXPERIMENTAL ANIMALS
EDWARD R. WOODWARD, M.D.;
PAUL V. HARPER, Jr., M.D.;
E. BRUCE TOVEE, M.D.;
LESTER R. DRAGSTEDT, M.D.
Arch Surg. 1949;59(6):1191-1212.
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THE PRESENCE of gastric secretory fibers in the vagus nerves and the activation of these nerves by conditioned and unconditioned reflexes involving the sight, odor, taste or thought of food were established by the classic researches of Pavlov and his associates. Pavlov considered the secretory fibers in the vagi to be the most important mode of activation of the gastric glands and was doubtful if gastric secretion could occur after these nerves had been divided. The work of numerous English and American physiologists has, however, subsequently demonstrated that an abundant secretion of gastric juice of normal composition can occur after complete vagotomy in experimental animals, and the mechanism of this secretion has been extensively studied. The contact of food substances with the mucosa of the stomach and intestine is thought to cause the elaboration of a chemical substance which is absorbed into the blood stream and stimulates the gastric glands
. . . [Full Text PDF of this Article]
Author Affiliations
CHICAGO
From the Department of Surgery of the University of Chicago.
Footnotes
This work has been aided by grants from the Otho S. A. Sprague Memorial Institute, from the Division of Research Grants and Fellowships of the National Institute of Health, United States Public Health Service and from the Douglas Smith Foundation for Medical Research of the University of Chicago.
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