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LESTER R. DRAGSTEDT, M.D.; EDWARD R. WOODWARD, M.D.; WILLIAM B. NEAL, Jr., M.D.; PAUL V. HARPER, Jr., M.D.; EDWARD H. STORER, M.D.

Arch Surg. 1950;60(1):1-20.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

ONE OF the obstacles encountered in a study of the physiology of gastric secretion is the difficulty of subjecting the normal stomach to the physiologic stimulus of food and making a quantitative collection of the gastric secretory output. In an attempt to simplify and control the many factors present, recourse has been made to various types of gastric pouches, fistulas and other preparations made with aseptic precautions in anesthetized animals. In most cases these preparations have proved compatible with survival in good health and with relative freedom from discomfort. Our present understanding of the mechanism of gastric secretion is largely dependent on these facts. Beaumont was the real pioneer in recognizing and utilizing surgical intervention as a method for the study of gastric physiology. The gastric fistula method in man used by him was subsequently employed with great advantage by Carlson¹ and, more recently, by Wolf and Wolff.² . . . [Full Text PDF of this Article]

Author Affiliations
CHICAGO

From the Department of Surgery of the University of Chicago.

Footnotes
This work has been aided by grants from the Committee on Research and Fellowships of the United States Public Health Service, from the Otho S. A. Sprague Memorial Institute and from the Douglas Smith Foundation for Medical Research of the University of Chicago.

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