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D. M. ENERSON, M.D.; E. R. WOODWARD, M.D.; E. B. TOVEE, M.D.; W. B. NEAL, Jr., M.D.; J. A. SIBLEY, M.D.; L. R. DRAGSTEDT, M.D., Ph.D.

Arch Surg. 1950;60(2):223-232.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

THE MANN-WILLIAMSON procedure of internal duodenal drainage is recognized as a convenient and consistent method of producing experimental peptic ulcers.¹ In from 90 to 100 per cent of dogs so prepared chronic progressive ulcers resembling the spontaneous ulcers of the stomach and duodenum in man develop. The availability of an experimental procedure which leads to the development of a specific disease in such a high percentage of cases obviously provides a most useful test object for the therapeutic effectiveness of various types of treatment. While this method was not employed by Dragstedt and his associates² when they introduced complete gastric vagotomy for the treatment of peptic ulcer in man, it has since been employed almost simultaneously in a number of different laboratories as a check on results coming from the clinic. During the progress of the present study, several workers have published results from similar experiments.

Harkins and . . . [Full Text PDF of this Article]

Author Affiliations
CHICAGO

From the Department of Surgery of the University of Chicago.

Footnotes
This work has been aided by grants from the Otho S. A. Sprague Memorial Institute and from the Division of Research Grants and Fellowships of the National Institute of Health, United States Public Health Service.

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