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Further Investigation of Hormonal Relationships

HERBERT BRENDLER, M.D.; WILLIAM E. CHASE, M.D.; WILLIAM WALLACE SCOTT, M.D.

Arch Surg. 1950;61(3):433-440.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

IN 1941 research in prostatic cancer received great impetus from the discovery by Huggins and his associates¹ that remarkable regression occurred clinically in the primary neoplasm and its metastases after castration or administration of estrogen. These findings were subsequently verified by others.² Unfortunately, the gratifying improvement manifested by most patients treated in this manner has since been found to be only temporary, and no actual cures have ever been recorded. Furthermore, postmortem studies on patients in whom no palpable or roentgenologic evidence of local or distant recurrence was evident just before death have shown extensive involvement of the prostate, bones and soft tissues. In all cases in which radical perineal prostatectomy has been done for advanced cancer after preoperative administration of estrogen, malignant cells have been readily demonstrated in the surgical specimens.³ We have thus been forced to conclude that although existing methods of endocrine manipulation have . . . [Full Text PDF of this Article]

Author Affiliations
NEW YORK; BALTIMORE

From the James Buchanan Brady Urological Institute, Johns Hopkins Hospital, Baltimore.

Footnotes
Read before the Section on Urology at the Ninety-Eighth Annual Session of the American Medical Association, Atlantic City, N. J., June 10, 1949.

This work was supported in part by the American Cancer Society's institutional grant to the Johns Hopkins University School of Medicine and in part by a grant from the National Brewing Company.

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