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WILLIAM J. GRACE, M.D.; CRANSTON W. HOLMAN, M.D.; STEWART WOLF, M.D.; HAROLD G. WOLFF, M.D.

AMA Arch Surg. 1950;61(6):1036-1051.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

OPPORTUNITIES to assess directly the effects of pharmacologic agents on large segments of exposed, intact human colon in the unanesthetized state have been rare. Such studies have been reported by Puestow¹ and Weeks,² and recently a new opportunity to study directly the appearance and function of the colon in four human subjects with fistulas became available. Previous reports have concerned themselves chiefly with motility functions. The present communication is based not only on observations of motility but also on a study of alterations in color, degree of engorgement and fragility of the mucous membrane.

SUBJECTS

Subject A was a 26 year old mechanic who had had chronic ulcerative colitis for six years. An ileostomy had been performed two years previously. Shortly after the ileostomy there occurred a large prolapse of ascending colon and cecum through an old cecostomy wound. The prolapsed area measured 7 by 2 inches (18 . . . [Full Text PDF of this Article]

Author Affiliations
NEW YORK

From the New York Hospital and the departments of medicine, surgery and psychiatry of Cornell University Medical College, New York, and the Veterans Administration Hospital, Bronx, N. Y.

Footnotes
Supported in part by grants from the Commonwealth Fund and the Estate of Lester N. Hofheimer.

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