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ROBERT C. DONALDSON, M.D.; EUGENE M. BRICKER, M.D.

AMA Arch Surg. 1951;62(1):118-124.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

STREPTOMYCIN, when given by mouth, produces a rapid reduction of the bacterial flora of the colon. However, this effect is only temporary in most cases, and streptomycin-resistant strains of bacteria rapidly repopulate the bowel. Because of this rapid development of resistant strains of bacteria, Lockwood¹ recommends that streptomycin should not be used for preoperative preparation of the bowel.

Recent observations by Mast and Harrison² and by Wooldridge³ indicate that glucuronolactone may aid streptomycin in producing and maintaining low bacterial counts in the intestinal tract. Glucuronolactone is an inner anhydride of glucuronic acid and forms on dehydration of the latter. Wooldridge and Mast⁴ demonstrated that this substance has certain antibacterial properties in vitro. Glucuronolactone in concentrations of 0.5 to 2.0 per cent was found to inhibit the growth of Escherichia coli. When glucuronolactone and streptomycin are combined in the test tube, the antibacterial effect against the test organisms is only slightly greater than when streptomycin is . . . [Full Text PDF of this Article]

Author Affiliations
JEFFERSON BARRACKS, MO.

From the Surgical Service of the Veterans Administration Hospital.

Footnotes
Sponsored by the Veterans Administration and published with the permission of the Chief Medical Director. The statements and conclusions published by the authors are the result of their own study and do not necessarily reflect the opinion or policy of the Veterans Administration.

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