This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citing articles on Web of Science (5)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

I. In Vitro Bacteriologic Evaluation on Peritoneal Exudate from Induced Fulminating Peritonitis

PAUL NEMIR, Jr., M.D.; H. H. ZINSSER, M.D.; E. E. LONG, M.S.; H. R. HAWTHORNE, M.D.

AMA Arch Surg. 1951;62(4):493-498.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

THE ACRIDINE group of antiseptics were used by surgical teams during part of the first World War and sporadically thereafter. During World War II. in an effort to find an effective agent in cases of resistance to penicillin and sulfonamides, the interest in the acridines was revived and remarkable success was reported with certain of the derivatives by British and Australian investigators.¹ Added stimulus has been supplied by the synthesis in recent years by Adrien Albert and his colleagues² of equally effective but less toxic derivatives, notably 2-7 diaminoacridine hydrochloride and 5-aminoacridine hydrochloride.

In 1945, one of us (H.R.H.) began using 5-aminoacridine hydrochloride in solution locally in infected wounds, in contaminated perineal wounds following abdominoperineal resection and in compound fractures with sepsis encountered in a civilian hospital. Sulfonamides, penicillin and supportive measures had been fully employed without appreciable effect on the local condition prior to the use of 5-aminoacridine. Although the . . . [Full Text PDF of this Article]

Author Affiliations
PHILADELPHIA

From the Harrison Department of Surgical Research Schools of Medicine, University of Pennsylvania and the Graduate Hospital.

Footnotes
Aided by a grant from the National Drug Company, Philadelphia.

The acridine drugs were kindly supplied to us by the National Drug Company.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?