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D. EMERICK SZILAGYI, M.D.; R. RALPH MARGULIS, M.D.; GILBERT D. JAY, III, M.D.

AMA Arch Surg. 1952;65(2):217-238.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

IN RECENT years, the pituitary-adrenocortical system has been shown experimentally and clinically to have an important and sometimes dominant role in the regulation of electrolyte,¹ carbohydrate,² protein,³ and fat⁴ metabolism, of hematopoiesis,⁵ of tissue cellular reaction,⁶ and of the enzymatic⁷ and antigenic⁸ systems of the body. Much evidence has also been produced that while the physiological integrity of the body is at all times dependent on the normal functioning of the pituitary-adrenocortical system, the adrenocorticotropic and adrenocortical hormones serve a purpose of particular importance in the defense of the body against noxious stimuli of all varieties.⁹ The well-known hypothesis of the adaptation syndrome of Selye¹⁰ endeavors to integrate this interplay of the manifold functions of the pituitary-adrenocortical system and the effects of nonspecific stimuli, or "stress," into a rational chain of physiological events.

On a priori grounds alone, one would . . . [Full Text PDF of this Article]

Author Affiliations
DETROIT

From the Division of General Surgery and Gynecology of the Henry Ford Hospital.

Footnotes
Read in part before the Section of Surgery, General and Abdominal, at the One-Hundredth Annual Session of the American Medical Association, Atlantic City, June 13, 1951.

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