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H. BROWNELL WHEELER, M.D.; JACK H. RUBENSTEIN, M.D.; M. DONALD COLEMAN, M.D.; THOMAS W. BOTSFORD, M.D.

AMA Arch Surg. 1952;65(2):283-289.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

INTRATUMOR injection of radioactive colloidal gold as a means of sharply localizing radiation within tumors was proposed in 1947 by P. F. Hahn.¹ Perhaps the main reason that widespread clinical use has not yet been made of this form of therapy is the technical difficulty of (1) insuring an even dispersion of the radioactive solution throughout the tumor, and (2) preventing the therapist from receiving hazardous amounts of radiation when he is working with high levels of activity. These technical problems can largely be overcome by use of the special equipment and techniques which are described in this paper.

PHYSICAL PROPERTIES OF AU¹⁹⁸

Au198 is produced from the stable isotope Au¹⁹⁷ by neutron bombardment in the chain-reacting pile at Oak Ridge. Since Au¹⁹⁷ has a high cross section capture for neutrons (100 barns), the production of Au¹⁹⁸ is reasonably efficient, and a high specific activity . . . [Full Text PDF of this Article]

Author Affiliations
BOSTON

From the Laboratories and Surgical Service of the Peter Bent Brigham Hospital and the Harvard Medical School.

Footnotes
This work has received support from the Atomic Energy Commission, from the American Cancer Society through an institutional grant to the Harvard Medical School, and from a grant from the American Cancer Society (Massachusetts Division), Inc.

Dr. F. D. Moore, Moseley Professor of Surgery at Harvard Medical School gave encouragement and advice throughout this work. Drs. Wheeler, Rubenstein, and Coleman carried out this investigation as a part of their undergraduate work in surgery at the Harvard Medical School. The apparatus described was constructed by Mr. F. C. Christenson at the Machine Shop of the Harvard Medical School.

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