This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

ROGER BAKER, M.D., Ph.D.; ROBERT GORDON, M.D.; JOHN HUFFER, M.D.; GEORGE H. MILLER, Jr., M.D.

AMA Arch Surg. 1952;65(5):702-705.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

ON THE basis of existing evidence the cause for failure of renal transplantation is due to the host developing antibodies in response to the foreign protein of the graft. This immune process is not only a natural phenomenon but also a valuable protective biological reaction. The present paper is concerned with methods of modifying or depressing this renal antigen-antibody response by use of nitrogen mustard (methyl bis [β-chloroethyl] amine hydrochloride), cortisone, and splenectomy. Philips, Hopkins, and Freeman,¹ and others² have demonstrated that nitrogen mustard will suppress development of antibodies. Germuth and co-workers³ have shown that cortisone is effective for states of hypersensitivity. Rich and co-workers⁴ have indicated also that cortisone inhibits antigen-antibody reactions. Persky and Jacob,⁵ however, failed to note any increased survival of renal transplantation in the cortisone-treated dog. The role of the spleen in the development of antibodies has been explored. After intravenous . . . [Full Text PDF of this Article]

Author Affiliations
CHICAGO

From the Department of Surgery (Division of Urology), University of Chicago, The School of Medicine.

Footnotes
This investigation was supported in part by grants from the United States Public Health Service and by Fred Goldberg and Harvey Goldberg.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?