This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citing articles on Web of Science (4)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

WATTS R. WEBB, M.D.

AMA Arch Surg. 1952;65(5):770-773.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

HYALURONIDASE has been shown to increase the rate of spread of fluid injected into subcutaneous tissues,¹ and thereby accelerate absorption of such fluids. Its action depends on the lysis of hyaluronic acid, the cementing agent in the intercellular ground substance, so that more surface area of cellular membrane is made available for equilibration and absorption. However, no quantitative studies have been reported on the effect of hyaluronidase under conditions of clinical use. I have already studied the apparent absorption rates of solutions commonly used for subcutaneous injection in clinical practice² which have served as controls for the present studies, designed to determine the effect of hyaluronidase, utilizing the same clinical technique.

METHODS

Isotonic (0.9%) sodium chloride solution and 5% glucose in water were injected subcutaneously in the thighs of eight patients who were in good clinical condition and who showed no evidence of dehydration or electrolyte imbalance. The . . . [Full Text PDF of this Article]

Author Affiliations
ST. LOUIS

From the Department of Surgery, Washington University School of Medicine, and Barnes Hospital.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?