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WILLIAM K. NOWILL, M.D.; C. RONALD STEPHEN, M.D.; PAUL W. SEARLES, M.D., M.S.

AMA Arch Surg. 1953;66(1):35-47.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

THE INTRODUCTION of a new drug into the field of anesthesiology is frequently received either with marked enthusiasm or marked disapproval. Trichloroethylene is one such drug. In England and Canada, since the report of Hewer, in 1942,¹ trichloroethylene has had wide application for the production of analgesia and light-plane anesthesia, particularly in the obstetrical field. In the United States, its use was somewhat discouraged by the report of Waters, Orth, and Gillespie, in 1943,² in which adverse effects on cardiac rhythm were noted. Other controversial reports continued to appear in the literature. Hamilton³ reported 26 deaths in 284 cases of industrial poisoning by trichloroethylene in German industry. However, Taylor⁴ tested trichloroethylene in experimental animals and found no adverse toxicological effects. McAuley,⁵ in 1943, reported three instances of postoperative bilateral trigeminal anesthesia in cases in which trichloroethylene had been used by the carbon-dioxide absorption technique. Later . . . [Full Text PDF of this Article]

Author Affiliations
DURHAM, N. C.; BUFFALO

From the Division of Anesthesia, Duke University Hospital, and Duke University School of Medicine, and the Department of Anesthesiology, Millard Fillmore Hospital, and University of Buffalo School of Medicine.

Footnotes
The obstetrical departments of Duke University Hospital and Millard Fillmore Hospital cooperated in these studies.

Read before the Section on Anesthesiology at the One Hundred and First Annual Session of the American Medical Association, Chicago, June 10, 1952.

Arterial blood studies were obtained with the assistance of Miss Regina Frayser and Dr. John Hickam, of the Duke University Hospital Respiratory Research Laboratory.

Cerebral blood flows and electroencephalographic tracings were obtained with the assistance of Drs. F. Wren and B. Bloor, and the neurosurgical department, Duke University Hospital.

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