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Treatment with Use of Chemotherapeutic Agents, Antibiotics, and Primary Closure; Follow-Up Report

FRANK D. DICKSON, M.D.; REX L. DIVELEY, M.D.; RICHARD H. KIENE, M.D.

AMA Arch Surg. 1953;66(1):60-68.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

WE GAVE a preliminary report in 1941 on the treatment of subacute and chronic osteomyelitis by a method in which, after a thorough débridement, sulfathiazole was used systemically and locally and a primary closure of the wound carried out.¹ Twenty-one cases were reported, 18 of which were of hematogenous origin. Primary healing was obtained in 82% of these cases. The following report includes a series of 104 cases, in which the same technique, with primary closure, was carried out in 140 procedures.

In discussing the treatment of subacute and chronic osteomyelitis, a definite distinction must be made between an infection of hematogenous origin and one which complicates a compound fracture or operative intervention. Although the pathological process in the bone may be the same, the reaction of the host is entirely different, for the resistance of the host to the Staphylococcus toxin is much lower in cases of osteomyelitis . . . [Full Text PDF of this Article]

Author Affiliations
KANSAS CITY, MO.

From the Dickson-Diveley Clinic.

Footnotes
Read before the Section on Orthopedic Surgery at the One Hundred and First Annual Session of the American Medical Association, June 10, 1952.

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