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Effect on Wound Healing, on Blood Protein and Electrolyte Levels, and on Response to Anesthesia

JAMES D. HARDY, M.D.; ANNE E. BORUM, M.D.; EDWARD J. PAVSEK, M.D.; JOHN K. ROBINSON, M.D.; JAMES E. SMITH, M.D.; ARTHUR F. ZIMMERMAN, M.D.

AMA Arch Surg. 1953;66(2):226-231.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

THE HEALING of wounds may be influenced by the serum protein level,¹ dehydration,² edema, local temperature,³ acidosis,⁴ and deficiencies of certain vitamins.⁵ The purpose of the present study has been to examine the effect of potassium depletion on wound healing. As the principal intracellular cation, potassium should have an important role in the fabrication of body tissue. Measurements of other plasma electrolytes have also been made.

METHODS

Mongrel dogs were weighed, given distemper injections, and later dewormed. After the animals had survived three weeks under observation, serum sodium and potassium levels were measured with the flame photometer,⁶ serum carbon-dioxide-combining power was measured by the method of Van Slyke,⁷ and serum chloride levels were measured with a modification of the Volhard method.⁸ Serum protein concentration was determined by the falling drop method of Barbour and Hamilton.⁹ Arterial blood was used, and the . . . [Full Text PDF of this Article]

Author Affiliations
MEMPHIS; PHILADELPHIA

From the Harrison Department of Surgical Research, the University of Pennsylvania School of Medicine, Philadelphia.

Footnotes
This work was aided by Contract No. DA-49-007-MD-84, between the University of Pennsylvania and the Office of the Surgeon General, Department of the Army.

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