This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citing articles on HighWire  • Citing articles on Web of Science (51)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

H. G. DOWNIE, D.V.M., M.S.(Cornell), M.V.Sc.

AMA Arch Surg. 1953;66(5):624-636.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

ONE OF the constant findings in a liverless dog is a progressive tachycardia. Consequently, 24 hours after hepatectomy the heart rate of the animal may be about 250 beats a minute. The animal otherwise may appear normal and walk about the room with little evidence to show that it has been subjected to a major operation. In an effort to elucidate the nature of this tachycardia my colleagues and I decided to connect the circulation of a liverless dog with that of a transplanted heart. If the transplant also shows tachycardia, one can be certain that this is a result of a humoral agency consequent upon removal of the liver. Because the technique of homotransplanting a heart turned out to be feasible, once we became familiar with it, we transplanted a series of 30 hearts, of which 23 survived. They beat on an average for 129 hours, and two hearts . . . [Full Text PDF of this Article]

Author Affiliations
GUELPH, ONT., CANADA

Associate Professor, Department of Physiology, Ontario Veterinary College.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?