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Changes in Morphology and Physiology of the Liver and an Attempt at Prognosis

JOHN A. MONCRIEF, M.D.

AMA Arch Surg. 1955;70(4):519-529.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

The purpose of this paper is to review the experimental and clinical facts pertinent to obstruction of the external bile ducts, with special reference to strictures, and to present the clinical, laboratory, and pathologic features of a collected group of cases in an attempt to formulate some basis for prognosis and treatment.

PREVIOUS WORK

How soon do clinical signs of extrahepatic obstruction appear in the experimental animal? In dogs, bile appears in the urine in 24 to 28 hours; scleral staining in 5 to 10 days, and generalized tissue icterus in 9 to 26 days after division and ligation of the common bile duct with the gall bladder intact.¹ General signs of illness appear in the dog as anorexia and apathy at four weeks. As early as two days, there is an abrupt rise in total cholesterol and esters which is maintained for four to six weeks and then . . . [Full Text PDF of this Article]

Author Affiliations
St. Louis

From the Department of Surgery, Washington University School of Medicine and Barnes Hospital.

Footnotes
Lauren V. Ackerman, M.D. reviewed the pathological specimens and Dr. Carl A. Moyer helped in the preparation of this manuscript.

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