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DAVID M. SKLAROFF, M.D.; EDWIN M. COHN, M.D.; THEODORE L. ORLOFF, M.D.; J. GERSHON-COHEN, M.D.

AMA Arch Surg. 1955;70(4):559-563.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Thirty years ago, Graham and Cole¹ published their report on a new method of visualization of the gall bladder based on the fundamental work of Abel and Rowntree.² Now, for the first time, a new substance is available, Cholografin, which, when administered intravenously, will produce roentgenographic visualization of the common bile duct in the presence or absence of the gall bladder.*

Cholografin is an isotonic and colorless solution of the disodium salt of N,N'-adipylbis (3-amino-2,4,6-triiodobenzoic acid) with the empirical formula C₂₀H₁₂O₆I₆Na₂. When first prepared by Schering, it was called Biligrafin. It contains 64% iodine which is molecularly stable and firmly bound even after injection into the blood stream. Cholografin is promptly and rapidly excreted by the liver. Its concentration in the common and hepatic ducts is sufficient for roentgen visualization within 20 minutes after intravenous injection (Fig. 1). A . . . [Full Text PDF of this Article]

Author Affiliations
Philadelphia

From the departments of Radiology and Gastro-Enterology of The Albert Einstein Medical Center, Northern Division; Associate in Radiology (Dr. Sklaroff); Associate in Gastro-Enterology (Dr. Cohn); Assistant, Dept. of Radiology (Dr. Orloff); Director, Dept. of Radiology (Dr. Gershon-Cohen).

Footnotes
Read before the Section on Surgery, General and Abdominal at the 103rd Annual Meeting of the American Medical Association, San Francisco, June 24, 1954.

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