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CHARLES A. MACGREGOR, M.D.; JOSEPH B. GRIFFITH, M.D.; GORDON A. MUNRO, M.D.

AMA Arch Surg. 1955;71(3):395-403.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Liver failure and death following surgery on patients with obstructive jaundice are not uncommon. Such a postoperative course is usually manifested in part by a febrile coma, a rising level of serum bilirubin, and a falling level of cholesterol esters and albumin. There can be little doubt that the operation in some way has directly influenced the course of the patient. The specific etiological details, however, are rather obscure. The relative importance of such details is difficult to assess from clinical cases. Some of these factors are the impaired liver function existing preoperatively, the anesthesia, the nonspecific stress of the operation and coincident hypoxia or sepsis.

In an effort to clarify the problem by experimental observations the authors have undertaken a series of studies to evaluate the relative importance of each factor. A detailed and thorough analysis of the course of liver function in dogs with simple uncomplicated obstructive jaundice . . . [Full Text PDF of this Article]

Author Affiliations
Denver

From the Department of Surgery, University of Colorado School of Medicine.

Footnotes
Received for publication April 25, 1955.

Read at the 12th Annual Meeting of the Central Surgical Association, Chicago, Feb. 18, 1955.

Supported by a grant from the Public Health Service, National Institute of Health, Bethesda, Md.

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