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THOMAS L-Y. DAO, M.D.; CHARLES HUGGINS, M.D.

AMA Arch Surg. 1955;71(5):645-657.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

The treatment of mammary cancer by endocrine methods rests on the concept of hormonal dependence, which characterizes many of these neoplasms. It has been shown that some methods of alterations in endocrine balance can constitute effective palliation in many cases. Surgical castration and administration of sex steroids have been used as the chief therapeutic armamentarium for metastatic cancer of the breast in the past decade and a half. In 1951 an important method of treatment of the disease was introduced by the finding that in certain types of mammary cancer there is an adrenal component which sustains and propagates the disease.¹ Surgical excision of the adrenal glands in patients maintained on cortisone has proved to be effective in producing regression of mammary cancer in certain cases.*

In his Hunterian lecture Cade¹¹ commented, "Bilateral adrenalectomy is an encouragement in the pursuit of an ideal which is to control cancer . . . [Full Text PDF of this Article]

Author Affiliations
Chicago

From the Ben May Laboratory for Cancer Research of the University of Chicago.

Footnotes
Submitted for publication June 23, 1955.

This study was aided by grants from the Jane Coffin Childs Memorial Fund for Cancer Research, from the American Cancer Society on recommendation of the Committee on Growth of the National Research Council, and from the Illinois Division of the American Cancer Society. Cortisone was provided by Merck & Co., Inc., Rahway, N. J.

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