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Experimental Studies on the Secretions of the Isolated Duodenum
JOHN H. LANDOR, M.D.;
PETER H. BRASHER, M.B. (London;
LESTER R. DRAGSTEDT, M.D.
AMA Arch Surg. 1955;71(5):727-736.
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There has long been an interest in the role played by the duodenum in gastrointestinal physiology. Numerous reports have appeared describing the secretions of the duodenum and the regulatory role played by the duodenum in the control of secretions from the stomach, gall bladder, and pancreas. However, much that is known about duodenal physiology has been learned indirectly by intubation of patients or animals and by the study of isolated short segments of duodenum. These methods, while they have been productive of much valuable information, have severe limitations. Though Walters and Bollman1 succeeded in completely isolating the duodenum, they made no attempt to study the secretion quantitatively.
In this laboratory methods have been developed for the quantitative collection of gastric juice from dogs. With modern operative techniques, as well as a better understanding of fluid and electrolyte balance, it has been possible to prepare many types of gastric pouch
. . . [Full Text PDF of this Article]
Author Affiliations
Chicago
From the Department of Surgery of the University of Chicago.
Footnotes
Submitted for publication April 16, 1955.
This work has been aided by grants from the Otho S. A. Sprague Memorial Institute and from the Division of Research Grants and Fellowships of the National Institutes of Health, United States Public Health Service.
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