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Experience with Corticotropin and Corticosteroids in Severe Peritonitis
GEORGE C. HENEGAR, M.D.;
ARTHUR J. HUNNICUTT, M.D.;
LAURANCE W. KINSELL, M.D.
AMA Arch Surg. 1956;73(5):804-812.
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It is generally recognized that the patient with an adrenocortical insufficiency has a poor tolerance to infection, even of a minor nature. It is also recognized that an overwhelming sepsis may produce a relative adrenal insufficiency. With the isolation and development of the adrenocorticotropic hormone of the pituitary and the various steroids of the adrenal cortex, an impetus was given to the study of the effects of these hormones on patients with severely toxic states.* Kass, Ingbar, and Finland showed that the course of a severe penumococcus pneumonia could be altered by the use of hormones alone.7 These experiences by others led to the use of corticotropin in the case of a child who was severely toxic from a generalized peritonitis. The changes produced in this child were striking. Within 24 hours, the patient who had been moribund was clinically less toxic, had active peristalsis in contrast to a
. . . [Full Text PDF of this Article]
Author Affiliations
Oakland, Calif.
From the Department of Surgery and the Institute for Metabolic Research, Highland Alameda County Hospital.
Footnotes
This work has been supported in part by grants from the Armour Laboratories; Merck and Company, Inc.; Schering Corporation; Pfizer Laboratories, Division of Charles Pfizer and Company, Inc., and the Upjohn Company. Armour Laboratories furnished supplies of corticotropin; Merck and Company, Inc., supplies of cortisone, hydrocortisone, and hydrocortisone hemisuccinate, and Upjohn Company, hydrocortisone hemisuccinate.
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