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HARRY S. THOMSON, M.D.; GEORGE MARGOLIS, M.D.; KEITH S. GRIMSON, M.D.; HAYWOOD M. TAYLOR, Ph.D.

AMA Arch Surg. 1957;74(1):39-49.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

The literature pertaining to the development of aortography and to the occasional occurrence of serious injury of the spinal cord, mesenteric circulation, or kidneys has been referred to in previous reports from our laboratories^1,2 and has been reviewed more recently by McAfee and Willson.³ Many authors emphasize the potential toxicity of contrast media to the kidney and the spinal cord. Our first report described an experimental method for producing injury of the spinal cord in dogs and compared the toxicity of two contrast media. Studies have continued in dogs in an attempt to standardize a similar technique for producing injury of a kidney. Idbohrn and Berg⁴ have investigated injury of the rabbit's kidney by intra-arterial injection of contrast media and have reviewed earlier literature on experimental renal injury.

In our first study two contrast media were compared, sodium acetrizoate (Urokon Sodium) and iodopyracet (Diodrast). In the present . . . [Full Text PDF of this Article]

Author Affiliations
Durham, N. C.

From the Departments of Surgery, Pathology, and Biochemistry, Duke University School of Medicine.

Footnotes
Submitted for publication July 20, 1956.

Acetrizoate and diprotrizoate were furnished by Mallinckrodt Chemical Works; iodopyracet and ditrizoate, by Winthrop-Stearns, Inc.

Presented at the Fourth Scientific Meeting of the North American Chapter of the International Society of Angiology, Chicago, June 9, 1956.

This investigation was supported by a research grant (G-869) from the Division of Research Grants, National Institutes of Health, U. S. Public Health Service.

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