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The Use of Arterial Implants Prepared by Enzymatic Modification of Arterial HeterograftsII. The Physical Properties of the Elastica and Collagen Components of the Arterial Wall
NORMAN ROSENBERG, M.D.;
JOHN HENDERSON, M.D.;
JOCELYN F. DOUGLAS, Ph.D.;
GEOFFREY H. LORD, D.V.M., Ph.D.;
EUGENE R. L. GAUGHRAN, Ph.D.
AMA Arch Surg. 1957;74(1):89-95.
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In a previous report1 the use of enzyme-digested heterografts as arterial substitutes was described. Bovine arteries were stripped of most of their parenchymatous proteins by controlled enzyme action, leaving a tubular prosthesis composed mostly of collagen. These tubes were implanted into dogs as aortic substitutes with the hope that, with most of their immunologically reactive proteins removed, the implants would be better tolerated by the host while yet maintaining their effectiveness as arterial substitutes. Short-term observations (up to one year) seemed to corroborate this hypothesis.
Since the advent of arterial grafting and the blood vessel bank, the concept has gained acceptance that the integrity of the elastica greatly contributes to the strength of a graft. However, much of the older literature is opposed to that hypothesis. In 1939, by ingeniously calculating Young's modulus * for different weight applications, Krafka2,3 was able to show that moduli obtained for the collagen
. . . [Full Text PDF of this Article]
Author Affiliations
Highland Park, N. J.; New Brunswick, N. J.
From the Vascular Services of Middlesex General Hospital, St. Peters General Hospital, and the Johnson and Johnson Research Foundation, New Brunswick, N. J.
Footnotes
Submitted for publication July 6, 1956.
Presented at the Fourth Scientific Meeting of the North American Chapter of the International Society of Angiology, Chicago, June 9, 1956.
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