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Débridement and Healing of Infected Wounds, Several with Metallic Foreign Bodies

EUGENE E. CLIFFTON, M.D.

AMA Arch Surg. 1957;74(2):207-214.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Enzyme therapy of infected wounds and ulcerating lesions is a rapidly developing field, in which there is great promise. It is said that John Hunter used crude pancreatic enzymes in the treatment of wounds. The maggot treatment of dirty chronic infected wounds and osteomyelitis cavities was undoubtedly effective because of proteolytic enzymes secreted by the maggots.¹ The modern methods of enzyme treatment using purified materials have been developed only in recent years.² Papain³ was used as long ago as the First World War for cleansing of infected burns and dirty wounds but was abandoned because of the severe irritation it caused. It was with streptokinase and streptodornase⁴ that the first well-controlled studies of this type of therapy were made.^5-8 Trypsin, a proteolytic enzyme obtained from the pancreas, is a stronger digestive enzyme, which has been used with success in debridement.^9-11 Bovine plasmin (fibrinolysin) has . . . [Full Text PDF of this Article]

Author Affiliations
New York

Associate Professor of Clinical Surgery, Cornell University School of Medicine, and Associate and Head of the Enzyme Research Section, Sloan-Kettering Institute.; From Andre and Bella Meyer Physiology Laboratory (Enzyme Research Section) of the Sloan Kettering Institute for Cancer Research and the Memorial Center for Cancer and Allied Diseases.

Footnotes
Submitted for publication May 29, 1956.

This research was supported by the United States Public Health Service under Grant C 2009.

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