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WILLIAM SILEN, M.D.; DEAN L. MAWDSLEY, M.D.; WILLIAM L. WEIRICH, M.D.; HAROLD A. HARPER, Ph.D.

AMA Arch Surg. 1957;74(6):964-973.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

There is considerable evidence that impairment of hepatic function occurs when the hepatic blood flow is reduced. Whipple¹ and Knutti² have shown that production of hemoglobin and serum proteins in animals with an Eck fistula is below normal. Harper et al.³ have found decreased tolerance to orally administered amino acids in dogs with Eck fistulas. Several authors have found clinical evidence of progressive deterioration of hepatic function following surgically constructed portacaval shunts.^4,5 Reduction of hepatic blood flow has also resulted in impairment of regeneration of liver tissue. Mann and Magath⁶ have shown that there is an almost complete disappearance of the regenerative capacity of the liver following the production of an Eck fistula. On the other hand, the liver will regenerate very well when a portacaval transposition has been carried out, indicating that portal blood per se is unnecessary for regeneration of the liver.⁷ . . . [Full Text PDF of this Article]

Author Affiliations
San Francisco

From the Surgical Research Laboratories of the University of California School of Medicine.

Footnotes
Read at the 64th Annual Meeting of the Western Surgical Association, Cincinnati, Dec. 1, 1957.

Supported by the Christine Breon Fund for Medical Research and by a research grant (A-1053) from the National Institute of Arthritis and Metabolic Diseases, National Institutes of Health, U. S. Public Health Service.

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