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Alkali and Acid in Shock Treatment

FREDERICK M. ALLEN, M.D.

AMA Arch Surg. 1957;75(2):210-223.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

The existing situation in the fluid therapy of shock has been accurately summarized by Wiggers.¹

It is generally suspected that the beneficial effects of sodium chloride do not depend solely or largely on its ability to restore plasma volume. It must be due to the action of the sodium or chloride ions or of the NaCl molecule.

Illustrative of the first sentence is the superiority of saline over plasma^2-5 or dextran solution.⁶ The problem of the second sentence is explored in the present paper.

Methods

Tourniquet shock, which was first standardized in rats,² was produced in dogs by tight constriction of both hindlegs as high as possible with heavy rubber bands or 6 mm. tubing. Anesthesia was induced with pentobarbital (Nembutal) intravenously or intraperitoneally. The animals were awake toward the end of the ligation period, when the limbs had lost sensation. Such constriction for five hours . . . [Full Text PDF of this Article]

Author Affiliations
New York

From the New York City Hospital, Welfare Island.

Footnotes
Organon, Inc., furnished the heparin solution (Liquaemin Sodium) used in all the hemorrhagic shock experiments.

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