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JOHN B. FULLER, M.D.; JOHN H. SCHNEEWIND, M.D.

AMA Arch Surg. 1957;75(3):462-470.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

The adrenal gland responds to the stress of surgical procedures by an increase in cortical hormone output, and about 80% of these steroids are reported to be in the form of hydrocortisone—one of the 17-hydroxycorticoids. These substances are related to carbohydrate and protein metabolism, as well as having anti-inflammatory and antipyretic properties. The other 20% of adrenal output includes hormones, such as aldosterone, which primarily affect electrolyte and fluid balance.

Despite lack of knowledge of the way in which these hormones act on cells and of their disposition in body fluid compartments, it is becoming increasingly clear that there is a direct relation between liver function and adrenal corticoid metabolism. It has been shown¹ that after infusions of hydrocortisone in normal subjects 50% of the hydrocortisone had left the plasma in 114 minutes. In patients with cirrhosis, however, it required 160 to 800 minutes for 50% of the steroid . . . [Full Text PDF of this Article]

Author Affiliations
Chicago

From the Department of Surgery, Research and Educational Hospitals, University of Illinois.

Footnotes
Submitted for publication March 4, 1957.

These studies were supported in part by a grant from The Upjohn Company, Kalamazoo, Mich.

Dr. H. C. Batson gave valuable assistance in statistical analysis of our data. Miss Lynn Miller gave excellent technical help.

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