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Technique and Results of Isolation of Cancer Cells from the Circulating Blood
STUART ROBERTS, M.D.;
ALVIN WATNE, M.D.;
RUTH McGRATH, B.S.;
ELIZABETH McGREW, M.D.;
WARREN H. COLE, M.D.
AMA Arch Surg. 1958;76(3):334-346.
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The invasion of veins by many malignant tumors has been shown by numerous investigators,1-4 but reports of the actual cytologic demonstration of cancer cells in the circulating blood have been relatively few,5,6 due to the technical difficulty in the separation and identification of the few cancer cells from the numerous formed elements of the blood. This study is a continuation of work begun four years ago7 and concerns the technique for the isolation of cancer cells from the blood and the occurrence of these cancer cells in the circulating blood, including the changes wrought by the manipulation incident to surgery.
Historical Review
Demonstration of Cancer Cells in Venous Blood.
—In 1869, Ashworth8 found cells in the blood which were of the same size and appearance as those of the patient's multiple malignant skin tumors. Schleip,9 in 1906, described cells varying from the normal in a
. . . [Full Text PDF of this Article]
Author Affiliations
Chicago
From the Departments of Surgery and Pathology, University of Illinois College of Medicine.
Footnotes
Submitted for publication Nov. 18, 1957.
Supported in part by a grant from the American Cancer Society, Illinois Division.
The staining technique and criteria for interpretation of this material are those described in Papanicolaou, G. N.: Atlas of Exfoliative Cytology, Cambridge, Mass., Harvard University Press, 1954.
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