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JACK A. CANNON, M.D.; PAUL I. TERASAKI, Ph.D.; WILLIAM P. LONGMIRE, Jr., M.D.

AMA Arch Surg. 1958;76(5):769-773.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Induced tolerance to homografts obtained by embryonic injection of the host with cells of the future donor is a phenomenon which has received extensive attention since the first report on the subject was made by Billingham and associates¹ in 1953. Until recently, such induced homograft tolerance was considered a highly individual-specific matter. In order to produce tolerance in a given individual, the evidence seemed to indicate that living cells from the individual future donor must be injected into the individual future host during the embryonic period of the host. Our recent studies of the homograft problem have dealt with induced tolerance in the chick. The technique of inducing tolerance between 10- to 16-day-old, incubated chick embryos has been described elsewhere² (Fig. 1). The presence or absence of tolerance is tested by interchanging skin homografts between 1-day-old or 14-day-old chicks; this technique has also been described elsewhere.³

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Author Affiliations
Los Angeles

From the Department of Surgery, University of California Medical Center.

Footnotes
This work was supported by Grant-in-Aid No. RG-4388 of the U. S. Public Health Service.

Read at the 65th Annual Meeting of the Western Surgical Association, Salt Lake City, Nov. 22, 1957.

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