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Inhibitory Effect on Gastric Secretion of Acid in Response to Test Meal

FERNAND R. SCHMIDT, M.D.; GEORGE A. HALLENBECK, M.D.

AMA Arch Surg. 1958;77(1):26-32.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

It has been recognized for many years that unneutralized gastric acid inhibits further secretion of acid by the stomach, thus providing an autoregulatory mechanism for control of secretion of acid. According to Babkin,¹ Sokolov in Pavlov's laboratory, using dogs with gastric and duodenal fistulas and complete separation of stomach and duodenum, found that introduction of 0.5% solution of hydrochloric acid into the stomach or of gastric juice into the duodenum inhibited secretion from a Pavlov pouch. Subsequent studies have shown that acid instilled into the duodenum can inhibit the secretory response of Pavlov pouches to (1) the cephalic phase of gastric secretion induced by sham feeding,² (2) the intestinal phase of gastric secretion induced by putting food into a duodenal fistula,² (3) the feeding of a meal of meat,^3,4 (4) the injection of histamine,³ and (5) the oral administration of ethanol.³ Code and Watkinson . . . [Full Text PDF of this Article]

Author Affiliations
Rochester, Minn.

Fellow in Surgery, Mayo Foundation (Dr. Schmidt). Section of Surgery, Mayo Clinic and Mayo Foundation (Dr. Hallenbeck). The Mayo Foundation, Rochester, Minn., is a part of the Graduate School of the University of Minnesota.

Footnotes
Submitted for publication Jan. 20, 1958.

Abridgment of thesis submitted by Dr. Schmidt to the Faculty of the Graduate School of the University of Minnesota in partial fulfillment of the requirements for the degree of Master of Science in Surgery.

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