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ISIDORE COHN, Jr., M.D., D.Sc. (Med.); ALFRED B. LONGACRE, M.D.

AMA Arch Surg. 1958;77(2):224-229.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Interest in antibacterial agents for preoperative preparation of the bowel has stimulated us to evaluate new agents by standardized techniques which permit comparisons of different agents.^1,2,7 Ristocetin, isolated from the actinomycete Nocardia lurida recovered from a Colorado soil sample, has been reported to be particularly effective against staphylococcal infections and not to induce bacterial resistance as easily as some other antibiotics.^9-12 The rising incidence of staphylococcal problems made this substance an interesting drug to evaluate for preoperative intestinal antisepsis.

Methods

Patients in good general condition were chosen at random from the surgical service,* provided they had no known colonic lesions. During the period of study they received only those antibacterial agents administered for intestinal antisepsis. The patients were not subjected to surgery during the period of investigation.

After a control stool was obtained, the patients were placed on a program similar to that for patients being prepared for . . . [Full Text PDF of this Article]

Author Affiliations
New Orleans

Department of Surgery, Louisiana State University School of Medicine.

Footnotes
Submitted for publication March 14, 1958.

Bacteriologic determinations were conducted by Bette M. Beauclair, B.S., and Esther C. Alexander, B.S.

Ristocetin was supplied by Abbott Laboratories as Spontin. Ristocetin-neomycin was supplied by Abbott Laboratories as Spontin-Neomycin.

Aided in part by Research Grants No. E-1600 and E-524-(C4) from the National Institute of Allergy and Infectious Diseases of the National Institutes of Health, U. S. Public Health Service.

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