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ABRAHAM KAPLAN, M.D.; BERNARD FISHER, M.D.

AMA Arch Surg. 1958;77(3):319-330.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

The two greatest deterrents to a more general acceptance of hypothermia as a clinical modality have been (1) the fear of ventricular fibrillation^1,2 and (2) the fear that hypothermia and rewarming will result in profound pathologic^3-5 and metabolic^6-8 changes which are difficult to correct or are irreversible. It has been felt by us that if, in spite of the control of fibrillation, the latter anxiety is justified, then serious consideration to the abandonment of clinical hypothermia is warranted.

A systematic evaluation of the effects of short and prolonged body cooling followed by rewarming has been made during the last three years by this laboratory. Information concerning the liver,⁹ cardiovascular systems,^10,11 general pathology and histochemistry,¹² and various metabolic parameters^13-15 has been reported. From these experimental findings and a critical evaluation of the literature it is believed that there is no conclusive evidence to suggest . . . [Full Text PDF of this Article]

Author Affiliations
Pittsburgh

John and Mary Markle Scholar (Dr. Fisher).; From the Department of Surgery, Section of Experimental Surgery, University of Pittsburgh School of Medicine.

Footnotes
Submitted for publication March 28, 1958.

Aided by the Western Pennsylvania Heart Association and U. S. Public Health Service Grant H-2065.

Read at the 15th Annual Assembly of the Central Surgical Association, Columbus, Ohio, Feb. 20, 1958.

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